Blood tests on study participants who stayed awake until 6am for three nights in a row showed the profound impact late nights have on hormones

Working night shifts can mess up the body’s natural rhythms so much that the brain and digestive system end up completely out of kilter with one another, scientists say.

Three night shifts in a row had little impact on the body’s master clock in the brain, researchers found, but it played havoc with gut function, throwing the natural cycle out by a full 12 hours.

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